Indomethacin popularly known as indocid in Nigeria, is a nonsteroidal anti-inflammatory drug commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms.It was introduced in 1963 for the treatment of rheumatoid arthritis, degenerative joint diseases, ankylosing spondilitis, gout, acute musculoskeletal disorders, inflammation and oedema following surgical technique and pain associated with primary dysmenorrhoea.
However, due to the high incidence and severity of side-effects associated with long-term administration, indomethacin is not commonly used for therapy as an analgesic or antipyretic again. Currently, there is less human usage or commercial demand for the drug which therefore makes it relatively cheap and available in most third world countries, especially in Nigeria
Why are Rodents like Rats Dangerous?
Rats cause several problems and can’t be allowed to linger. The dangers of having rats in your home include:
- Damage to your property.
- The spread of disease, several of which can be fatal.
- Contaminated food storage and preparation areas.
- The risk of fires from chewed wires.
How Indocid Kills Rats
Indomethacin has been found to be a good rodenticide, as adult rats usually die 2-4 days after consumption of doses between 86 to 250 mg/kg body mass. A capsule of indomethacin (25 mg) generously applied to baits like meat, fish, sausage or other food stuff and a significant number of such scattered in a rat-infested area will give almost 100% mortality in less than one week.
Indocid caused anorexia, dehydration and weakness, which became progressively worse with time; and there was 100% mortality within 36 and 82 hours in mice and rats, respectively.
How to Keep Rats Away
The best strategy is to keep these kind of pests out of your home to start with. Once an infestation has begun they are hard to get rid of. Here are eight steps you can take to keep these rodents out of your home:
- Fill holes, cracks and gaps
Rats can slip into holes the size of a quarter. Check your home for any opening that size and larger. Seal them up with proper materials. These include steel wool, hardware cloth, caulk, cement, and plaster. Weather-strip doors and windows if there are large cracks.
- Don’t feed them
Rats are resourceful. They will find things to eat around your property, so you have to be diligent in dealing with them. Cover garbage cans at all times. Pick produce from your garden and trees as it ripens. Pick up and compost fruit and vegetables that fall to the ground. Feed outdoor pets during the day and don’t leave leftover food lying around. Don’t store pet food outside without making sure it’s in rodent proof containers.
- Remove their habitat
Don’t give these vermin a place to live. Remove debris such as limbs, old cars or appliances from your property. If you have wood piles or lumber, store them at least 18 inches above ground and a foot or so away from your home and other walls. Remove heavy vegetation, as rats consider this is a great hiding place.
- Trim trees, shrubs and limbs back four feet from your home
Rats aren’t Olympians; they can’t bridge that gap.
- Set traps inside
There are several commercially available traps to catch rats inside your home that are not dangerous to pets and children, for example, cage traps.
- Use baits and poisons outside
Toxic baits and poisons should be used outside the home. Rats can spread poison inside your home, making it dangerous for all. Always read and follow label directions. Make sure rat bait is in an enclosed bait station. Keep the bait where children and pets can’t reach it.
- Check your neighborhood
Chances are, rats are a neighborhood issue. If you have a rat problem, it’s probably you won’t be the only one dealing with these rodents. Band together with neighbors to check community areas for rat activity. Take the same steps listed above in these areas.
- Call the pros
In general, the most effective step for eliminating rats is to call on professional rat exterminators when you see evidence of a rat infestation. Rats are dangerous, so it’s best not to take a chance when dealing with them. Expert help will give you much better results than working on your own.
Rats are one of the most frustrating household pests. They harbor diseases, they cause destruction to your house, and they contaminate your food. If you want to learn more about how to get rid of rats and many other household pest. See How To Kill Rats Instantly