What is the hippocampus?

Hippocampus is a region of the brain that is associated primarily with memory. The hippocampus, which is located in the inner (medial) region of the temporal lobe, forms part of the limbic system, which is particularly important in regulating emotional responses. It receives afferent inputs from the cingulate gyrus, dentate gyrus, contralateral hippocampus, parahippocampal gyrus, septal area, indusium griseum, and diencephalon.

Regarding efferent pathways, nerve fibers from the hippocampus proceed directly from the subiculum to the entorhinal cortex and amygdala, as well as through the fornix to different anterior brain structures.


What are the functions of the hippocampus?


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Being an integral part of the limbic system, the hippocampus plays a vital role in regulating learning, memory encoding, memory consolidation, and spatial navigation.


What would happen if the hippocampus was damaged?
If one or both parts of the hippocampus are damaged by illnesses such as Alzheimer’s disease, or if they are hurt in an accident, the person can experience a loss of memory and a loss of the ability to make new, long-term memories.


Hippocampus and memory

Hippocampus is divided into three regions: CA1, CA2, and CA3. These regions form the trilaminar loop, which is the processing center of long-term memory. Long-term potentiation (LTP), which is a form of neural plasticity, occurs in the hippocampus, and LPT is a vital brain mechanism involved in memory storage.  The complex processes of memory encoding in the hippocampus and retrieval of experiences from the frontal lobe involve two prominent pathways: polysynaptic and direct pathways. In the polysynaptic pathway, the hippocampus receives afferent inputs via axons of the entorhinal cortex, which terminate in the dentate gyrus. From there, neurons of the dentate gyrus send mossy fibers to the neurons of pyramidal cells located in CA3. These pyramidal cell neurons are further divided into two branches: one branch reaches the opposite side of the hippocampus via the corpus callosum; the other branch connects to CA1 through Schaffer collateral pathways. From there, the projections leave the hippocampus to return to the inferior temporal cortex, temporal pole, and prefrontal cortex. The polysynaptic pathway is important for semantic memory (facts and concepts), and the direct pathway is important for the episodic (recollection of events) and spatial memory (recognition).


Hippocampus and learning

Pyramidal cells of the hippocampus play an essential role in classical eyeblink conditioning, which is a standard model for studying associative learning. Studies involving delayed eyeblink conditioning have revealed that pyramidal cells form a predictive paradigm of the time-amplitude sequence of the learned behavioral response. The rate of acquisition can be impaired or increased by hippocampal manipulations. In this form of the learning process, the hippocampus plays an important role in trace conditioning wherein a short interval is imposed between the condition and unconditioned stimuli. After eye blink conditioning, long-lasting neuronal plasticity is generated in the hippocampus, which is needed for the learning process in trace eyeblink conditioning.


Hippocampus and spatial navigation

One of the major functions of the hippocampus is forming a cognitive map, which is a type of mental representation related to the acquisition, coding, storing, recalling, and decoding of information on relative locations within a specific environment. Place cells, a type of pyramidal cell, are mainly involved in hippocampus-mediated spatial navigation. These cells are activated when an animal enters a particular place in its environment (place field); however, these cells remain silent when an animal is moving outside the place field. Besides place field, the firing rate of place cells depends on the direction of movement, the direction of the destination, or other task-related factors.


Hippocampus and behavior

The hippocampus plays a vital role in flexible and goal-directed behavior. An intact hippocampal activity is required for forming and reconstructing relational memory (required for remembering arbitrary associations between objects or events) associated with flexible cognition and social behavior. Many studies have revealed that any damage to the hippocampus can impair the flexible use of information and produce maladaptive behavior.

The role of the hippocampus in behavioral inhibition is also well-established in the literature. The link between hippocampus and inhibition has been derived mainly from two basic observations: 1st observation is that damage to the hippocampus makes animals hyperactive; 2nd observation is that damage to the hippocampus reduces the learning ability of animals to inhibit responses that they have learned previously.

Hippocampus acts as an evaluation center associated with behavioral inhibition, obsessional thinking, scanning, and spatial map formation. However, the hippocampus does not actively participate in controlling behavior, once an experience is characterized. External stress-induced increased corticosterone level eventually reduces the firing rate of the hippocampus.

Recently, a new hippocampal function has been put forward. It has been found that low-frequency firing/activity in the hippocampus can influence the functional integration between spatially separated regions in the cerebral cortex, leading to increased sensory responses, such as vision, hearing, and touch.


Hippocampus  flexible cognition and social behavior

According to a study in the frontiers in  Human Neuroscience successful behavior requires actively acquiring and representing information about the environment and people, and manipulating and using those acquired representations flexibly to optimally act in and on the world. The frontal lobes have figured prominently in most accounts of flexible or goal-directed behavior, as evidenced by often-reported behavioral inflexibility in individuals with frontal lobe dysfunction. Here, we propose that the hippocampus also plays a critical role by forming and reconstructing relational memory representations that underlie flexible cognition and social behavior. There is mounting evidence that damage to the hippocampus can produce inflexible and maladaptive behavior when such behavior places high demands on the generation, recombination, and flexible use of information. This is seen in abilities as diverse as memory, navigation, exploration, imagination, creativity, decision-making, character judgments, establishing and maintaining social bonds, empathy, social discourse, and language use. Thus, the hippocampus, together with its extensive interconnections with other neural systems, supports the flexible use of information in general. Further, we suggest that this understanding has important clinical implications. Hippocampal abnormalities can produce profound deficits in real-world situations, which typically place high demands on the flexible use of information, but are not always obvious on diagnostic tools tuned to frontal lobe function.

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