How Long Does Percocet Stay In Your Urine

Percocet is a prescription painkiller that contains a combination of oxycodone (a semi-synthetic opiate) and acetaminophen (the active ingredient in Tylenol). Percocet provides relief for moderate to severe pain and lasts up to 3 to 5 hours depending on the formulation. OxyContin, another oxycodone-based painkiller can provide relief up to 12 hours, due to its time-release properties.

Percocet is a strong pain reliever most often prescribed for intense, short-term pain felt after surgery or trauma, but it is also sometimes used for patients with severe chronic pain. Percocet is often seen as a safer way to get high because it is legal to purchase.

However, Percocet is still widely abused for its narcotic effect. A high enough dose can result in a sense of euphoria similar to that experienced by heroin users. Abuse of Percocet can lead to addiction to Percocet or to something harder.

People who utilize oxycodone containing pills like Percocet may wonder how long the drug shows up on urine drug tests. A urine drug test, also known as a urine drug screen or a UDS, is a painless test. It analyzes your urine for the presence of certain illegal drugs and prescription medications. The urine drug test usually screens for a wide range of drugs including opioids. Alcohol can also be included in screening tests, but it’s usually detected through breath tests rather than urine screens.

A urine drug test can help a doctor detect potential substance abuse problems. After a drug test identifies drugs you may be misusing, doctors can help you start a treatment plan. Taking urine drug tests throughout substance abuse treatment helps to ensure that the plan is working and that you’re no longer taking drugs.


What is Percocet’s Half-Life?

Half-life is a term that refers to the amount of time it takes for a substance to reduce to half its initial amount in your body. For example, if you take a substance like Percocet, the half-life refers to how long it takes for the concentration of the substance in your body to decrease by half. Percocet’s half-life may also be helpful to estimate when withdrawal symptoms may occur.

Because the oxycodone component of Percocet is a short-acting, immediate-release drug, its half-life is estimated to be between 3.2 and 4 hours. Similarly, the acetaminophen component of Percocet has a half-life of around three hours. However, Percocet’s half-life range varies and may increase if you have poor kidney or liver function.


Factors That Influence How Long Percocet Stays In Your System

There are individual factors that can determine how long Percocet stays in your system:

  • Physiological Factors: A person with poor kidney or liver function may clear Percocet slower than a person with healthy kidney and liver function, leading the drug to last longer in their body.


  • Drug Interactions: Percocet has some drug interactions that can make the body clear Percocet more quickly than expected, including anti-infective rifampin and the seizure medications carbamazepine and phenytoin. Some medications can make Percocet stay longer in the body than expected, including antibiotics like erythromycin, the antifungal ketoconazole and the HIV medication ritonavir.


  • Dosage: The higher the Percocet dose you take and the more often you take it, the longer it may take your body to clear the drug.


On average, oxycodone stays in the urine for 2–4 days following the last dose. One 2013 study found an average duration of 30 hours following a single dose. However, the actual detection window varies due to several factors, including:


  • Hydration: Drinking a lot of water may dilute the urine, shortening the detection window.


  • Dosage: Smaller doses exit the body more quickly. The body can generally metabolize a single dose faster than it can metabolize many doses.


  • Metabolism: Some people’s bodies metabolize drugs faster than others.


Generally, it takes about five half-lives for a drug to be completely removed from your system. Based on a half-life of 4 hours, Percocet is likely to stay in your system for about 20 hours.


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