Klovinal® is a vaginal pessary that contains Clotrimazole, Metronidazole and Lactobacillus Spores. It is indicated for the treatment of vaginal infections- both fungal and bacterial infections such as Vulvovaginal Candidiasis( Toilet Infection), Bacterial Vaginosis and Trichomonas Vaginalis as well as restores a healthy vaginal floral. The vaginal flora are the bacteria that live inside the vagina. The normal vaginal flora are dominated by various lactobacillus species. Lactobacilli help to keep the vagina healthy by producing lactic acid, hydrogen peroxide, and other substances that inhibit the growth of yeast and other unwanted organisms.

Vaginal infections are one of the most common gynecological diseases with significant psychological and clinical implications. Vaginal infections can cause vaginal discharge, discomfort, and vaginal odor. However, these symptoms do not necessarily indicate an infection. Instead, they may result from other conditions that affect the vagina. For example, chemicals or other materials (such as hygiene products, bubble bath, laundry detergents, contraceptive foams and jellies, and synthetic underwear) can irritate the vagina and cause a discharge and discomfort. The inflammation that results is called noninfectious (inflammatory) vaginitis.

A vaginal discharge may be caused by a disorder that affects other reproductive organs, rather than the vagina. For example, a discharge can result from certain sexually transmitted diseases such as chlamydial infection or gonorrhea. The bacteria that cause these diseases can spread from the vagina to the cervix (the lower, narrow part of the uterus that opens into the vagina) and the uterus, causing pelvic inflammatory disease. Genital herpes, which can cause blisters on the vulva (the area around the opening of the vagina), in the vagina, and on the cervix, can also cause a vaginal discharge.


Why Klovinal is Effective

The topical association of clotrimazole-metronidazole in the Klovinal pessary represents a current reference treatment for these types of infections with a number of important pharmacological properties. This combination allows an effective activity against a broad spectrum of pathogens (bacterial, fungal and protozoan), a feature particularly relevant in the case of mixed infections. Furthermore, it allows a synergistic action that improve the therapeutic abilities of the individual components, a reduction of the spontaneous resistance of some microorganisms and the activity against symptoms and signs of vaginal inflammation with maintaining the vaginal ecosystem, since they have no activity against endogenous lactobacilli.


Using Klovinal for Pelvic inflammatory disease (PID

Pelvic inflammatory disease (PID) is an infection of the female reproductive organs. It most often occurs when sexually transmitted bacteria spread from your vagina to your uterus, fallopian tubes or ovaries. The signs and symptoms of pelvic inflammatory disease can be subtle or mild. It’s usually caused by a sexually transmitted infection (STI), like chlamydia or gonorrhea, and is treated with antibiotics. Klovinal cannot be used stand alone to teat PID even though it contain Metronidazole . Nevertheless it has been reported that women who received metronidazole with the CDC-recommended antibiotic regimen of ceftriaxone and doxycycline for pelvic inflammatory disease, or PID, experienced better clinical and microbiologic outcomes than women who received only ceftriaxone and doxycycline, according to a new study.


 Use Of klovinal During Pregnancy

In general, drugs should not be used during pregnancy unless necessary because many can harm the fetus. About 2 to 3% of all birth defects result from drugs that are taken to treat a disorder or symptom. Sometimes drugs are essential for the health of the pregnant woman and the fetus. Clotrimazole the main ingredient in Klovinal is generally considered safe for pregnant women to use. If you are using the pessary to treat vaginal thrush during pregnancy it is recommended that you insert it with your fingers rather than with the applicator provided. It is very common for pregnant women to suffer from thrush.

In Addition, there is no evidence to suggest that the other ingredient metronidazole places a pregnancy at risk at any stage. A recent study looked at over 900 women who had taken metronidazole sometime during their pregnancy and there was no increased risk for preterm birth (birth before 37 weeks), low birth weight, or congenital anomalies. Discuss with your doctor if you intend using klovinal during pregnancy.


Can A Virgin Use Klovinal

It is important to discuss using Klovinal with your doctor and family before using the medication as a virgin. Using the pessary to treat vaginal thrush will involve inserting it with your fingers or with the applicator provided which can break the hymen and cause you to bleed. The hymen is a thin piece of skin that partially covers the entrance to the vagina. It usually breaks during sex, if it hasn’t already broken before. The hymen can break quite easily before a woman has sex for the first time, through: activities such as horse riding and other sports or using tampons


Can Klovinal Be Used During Period

Few things feel worse than having a vagina infection when you’re on your period—that deep, invasive itch you can’t scratch is extra uncomfortable when it’s coupled with achey cramps and a whole lot of blood. One of the causes of thrush is a change in hormone levels, which happens when you have your period. If you  are menstruating you can use Klovinal to treat the infection or try an oral treatment alternative. Your period will not affect the treatment.

Nevertheless, It is suggested that Klovinal treatment be timed so as to avoid the menstrual period and to be completed before the onset of menstruation. If the treatment does coincide with a menstrual period, use sanitary pads not tampons during therapy.


Can Klovinal Delay Period

Although some people believe that vaginal yeast infection can cause a delay in the menstrual cycle, no proven medical deductions are confirming the same. Therefore, factually, yeast infections are not known to be responsible for affecting the schedule of your monthly periods in any way.

If your periods are irregular and if you’ve had vaginal infections  before, you may be wondering if vaginal infections  or the treatment can delay your period. While vaginal infections may not actually change the hormonal fluctuations that cause your period, it is possible that the infections may cause uterine contractions and/or a bit of spotting and bleeding. This may make you think that you’re getting your period, when you’re really dealing with a vaginal infection. And although vaginal infections cannot give you irregular cycles on its own, the infection may disrupt the overall bacterial balance in your vagina.

Also keep in mind that when bacterial vaginosis is left untreated, more serious conditions like pelvic inflammatory disease (PID) can arise. It’s important to pay attention to your monthly hormonal cycle to understand what is normal for you and to track any changes that may be occurring.


Other Potent Uses Of Klonival

This pessary is most often used for prolapse of the uterus. Prolapse means that your uterus droops or sags into the vaginal canal because the muscles and ligaments that should support it are weak. This may occur after you give birth or have pelvic surgery. Prolapse of the uterus is usually fixed with surgery, but you can also use a vaginal pessary to help keep the uterus in place

A pessary can help if you have a cystocele (when your bladder droops down into your vagina) or if you have a rectocele (when the wall of your rectum bulges into the bottom of your vagina).A pessary can also help many women who have stress urinary incontinence (the leaking of urine when you cough, strain or exercise). Pregnant women who have incontinence can also use a vaginal pessary.

The pessary sits high inside the vagina. When it is in the correct position you should not be able to feel it. After the pessary has been inserted you can resume all of your normal day to day activity, including sexual activity. In fact the pessary should improve your ability to be active as it supports the prolapse and should make you feel more comfortable.


Klovinal pessary is contraindicated in patients known to be hypersensitive to topical imidazoles


If irritation or sensistivity develops with the use of Klovinal pessary, treatment should be discontinued and appropriate therapy instituted.

If there is lack of response to Klovinal pessary treatment, microbiological studies should be done to confirm the diagnosis and rule out other pathogens before instituting other course of antimycotic therapy


Antibiotics with activity against lactobacilli should be avoided


Side Effects of Klovinal

Few patients have reported local pruritus and burning sensation after vaginal administration


Dosage & Administration

One [1] Klovinal  pessary should be inserted into the vagina as deeply as possible once daily.It should be used for six [6] days, preferrably on retiring to bed at night. The treatment should not be carried out during menstruation


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